Description

1-Hydroxypyrene-β-D-Glucuronide is a crucial conjugated metabolite of pyrene, formed via the glucuronidation pathway. This high-purity reference standard is essential for analytical calibration and method validation in environmental and biological monitoring. It is primarily used by researchers and quality control laboratories in the environmental testing, pharmaceutical, and toxicology sectors to accurately quantify exposure to polycyclic aromatic hydrocarbons (PAHs).

Application

• Biomarker Analysis: Serves as a critical reference standard for the quantification of 1-hydroxypyrene glucuronide in human urine, a key biomarker for assessing exposure to pyrene and other PAHs.
• Environmental Monitoring: Used in the development and validation of analytical methods (e.g., LC-MS/MS, HPLC) for detecting PAH metabolites in environmental and biological samples.
• Toxicology & Metabolism Studies: Employed in research to study the Phase II metabolism, pharmacokinetics, and detoxification pathways of pyrene and related compounds.
• Clinical Research: Acts as a calibrant in assays designed to monitor occupational or environmental health risks associated with PAH exposure.
• Pharmaceutical Impurity Profiling: Can be utilized as a standard in impurity identification and control strategies for compounds with similar structural motifs.
• Food Safety Testing: Supports method development for the analysis of PAH contaminants and their metabolites in food products and agricultural samples.

Basic Information

Product Name	1-Hydroxypyrene-β-D-Glucuronide
CAS No.	154717-05-2
Molecular Formula	C22H20O8
Molecular Weight	412.39 g/mol
Synonyms	1-Hydroxypyrene β-D-Glucuronide; 1-Hydroxypyrene Glucuronide; 1-Pyrenol Glucuronide; 1-Hydroxypyrene 1-O-β-D-Glucuronide; Pyren-1-yl β-D-Glucopyranosiduronic Acid; 1-HP-G; 1-OHP-Gluc; 1-Hydroxypyrene-1-O-β-glucuronide
EINECS	Contact for details

Quality Control

Our 1-Hydroxypyrene-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.