Description

Ac-Yvad-2,6-Dimethylbenzoyloxymethylketone CAS NO 154674-81-4 is a specialized synthetic organic compound featuring a protected ketone moiety. This molecule is of significant value in advanced organic synthesis and pharmaceutical research, serving as a key building block or intermediate. It is primarily utilized by research chemists and process development scientists working in medicinal chemistry and fine chemical production. The compound's structure makes it suitable for constructing complex molecular architectures under controlled conditions.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of protease inhibitors or other targeted therapeutics.
• Peptidomimetic Synthesis: Serves as a scaffold or protecting group strategy in the creation of peptide analogs and mimetics.
• Chemical Biology Probes: Employed in the development of activity-based probes for studying enzyme function and mechanism.
• Fine Chemical Production: An intermediate in multi-step synthetic routes for high-value, low-volume specialty chemicals.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory organic synthesis.

Basic Information

Product Name	Ac-Yvad-2,6-Dimethylbenzoyloxymethylketone
CAS No.	154674-81-4
Molecular Formula	C24H26N2O6
Molecular Weight	438.48 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-CH2OCO(2,6-Me2C6H3); Ac-YVAD-CHO (protected analog); N-Acetyl-L-tyrosyl-N-[(benzyloxy)carbonyl]-L-valyl-N-[(benzyloxy)carbonyl]-L-alanyl-L-aspartic acid α-(2,6-dimethylbenzoyloxy)methyl ketone; Caspase-1 Inhibitor, Ac-YVAD-CMK (related); Acetyl-Tyr-Val-Ala-Asp chloromethyl ketone derivative; ICE Inhibitor YVAD analog; Interleukin-1β Converting Enzyme Inhibitor precursor.
EINECS	Contact for details

Quality Control

Our Ac-Yvad-2,6-Dimethylbenzoyloxymethylketone is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.