Description

8-(4-Bromo-2,3-Dioxobutylthio)Nad is a specialized biochemical reagent featuring a reactive bromodioxobutylthio moiety linked to a nicotinamide adenine dinucleotide (NAD) core. This compound matters as a critical tool for researchers studying enzyme kinetics, metabolic pathways, and redox biology, particularly in the context of dehydrogenase inhibition and activity profiling. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and diagnostic kit manufacturers developing advanced assays.

Application

• Enzyme Inhibition Studies: Used as a mechanism-based inhibitor or active-site probe for NAD-dependent dehydrogenases.
• Biochemical Research: Serves as a substrate analog in metabolic pathway analysis and redox cofactor research.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) campaigns to identify novel therapeutic agents targeting specific enzymes.
• Diagnostic Reagent Synthesis: Acts as a key intermediate or component in formulating specialized diagnostic assays for clinical testing.
• Proteomics & Chemical Biology: Utilized for activity-based protein profiling (ABPP) to label and study enzyme families in complex biological samples.

Basic Information

Product Name	8-(4-Bromo-2,3-Dioxobutylthio)Nad
CAS No.	154591-46-5
Molecular Formula	C20H25BrN7O14P2S
Molecular Weight	769.36 g/mol
Synonyms	8-(4-Bromo-2,3-dioxobutylthio)NAD+; 8-BDB-T-NAD+; NAD analog, 8-(4-bromo-2,3-dioxobutylthio)-; Nicotinamide adenine dinucleotide, 8-(4-bromo-2,3-dioxobutylthio)-; 8-(4-Bromo-2,3-dioxobutylthio)nicotinamide adenine dinucleotide; BDB-T-NAD; Reactive NAD derivative
EINECS	Contact for details

Quality Control

Every batch of 8-(4-Bromo-2,3-Dioxobutylthio)Nad is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards expected for high-value biochemical reagents. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC), identity (NMR, MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.