Description

10-o-(3-(4-Azidobenzamido)Propionyl)Ryanodine is a chemically modified derivative of the natural alkaloid ryanodine, designed as a potent and photoactivatable molecular probe for studying intracellular calcium release channels (ryanodine receptors, RyRs). This compound is critical for advanced biochemical and pharmacological research, enabling precise, light-controlled manipulation of RyR activity to investigate muscle contraction, neuronal signaling, and cardiac function. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on cardiovascular, neurological, and muscular disorder research.

Application

• Photopharmacology Research: As a photoactivatable ("caged") ligand for precise, spatiotemporal control of ryanodine receptor (RyR) activity in live cells and tissues.
• Calcium Signaling Studies: A key tool for investigating the mechanisms of intracellular calcium release in cardiac, skeletal, and smooth muscle cells.
• Neuroscience Research: Used to study the role of RyRs in neuronal excitability, synaptic plasticity, and neurotransmitter release.
• Drug Discovery & Target Validation: Employed in high-throughput screening assays and mechanistic studies to identify and validate novel therapeutics targeting calcium channel disorders.
• Biochemical Probe Development: Serves as a precursor for developing affinity labels or fluorescent probes for RyR protein characterization and localization.
• Toxicology Studies: Applied in research examining the effects of environmental or pharmacological agents on calcium homeostasis and channel function.

Basic Information

Product Name	10-o-(3-(4-Azidobenzamido)Propionyl)Ryanodine
CAS No.	154505-02-9
Molecular Formula	C₃₈H₄₃N₅O₉
Molecular Weight	713.78 g/mol
Synonyms	10-O-[3-(4-Azidobenzamido)propionyl]ryanodine; 10-O-(3-(4-Azidobenzamido)propionyl)ryanodine; Caged Ryanodine; Photoactivatable Ryanodine; Azido-Benzamido-Propionyl Ryanodine; Ryanodine, 10-O-[3-[(4-azidobenzoyl)amino]-1-oxopropyl]-; ARyanodine; N₃-C6-Ryanodine
EINECS	Contact for details

Quality Control

Our 10-o-(3-(4-Azidobenzamido)Propionyl)Ryanodine is produced and handled under strict quality protocols to ensure the high purity and consistency required for sensitive research applications. Each batch is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the integrity of the photoactivatable azido group. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Photoactivation Efficiency	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.