Description

Beauveriolide I is a potent and specific cyclic depsipeptide inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). This compound matters for researchers as a critical pharmacological tool in the study of cholesterol metabolism and lipid droplet formation. It is primarily needed by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) focused on developing novel therapeutics for atherosclerosis, obesity, and related metabolic disorders.

Application

• Pharmacological Research: Used as a selective ACAT inhibitor to study intracellular cholesterol esterification and lipid storage pathways in cell-based assays.
• Drug Discovery: Serves as a reference standard and lead compound in the development of new anti-atherosclerotic and anti-obesity agents.
• Biochemical Mechanism Studies: Employed to elucidate the role of ACAT enzymes in foam cell formation, a key process in the development of arterial plaques.
• Academic Research: Utilized in university and institutional labs for fundamental research on lipid metabolism and cellular biology.
• Biomarker Research: Can be applied in studies investigating lipid droplet dynamics as biomarkers for metabolic health.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in related pharmaceutical analysis.

Basic Information

Product Name	Beauveriolide I
CAS No.	154491-55-1
Molecular Formula	C₄₅H₇₄N₄O₉
Molecular Weight	815.1 g/mol
Synonyms	Beauveriolide I; ACAT Inhibitor Beauveriolide I; Cyclo[L-Phe-D-Hiv-L-Leu-D-(α-OH)Leu]; Cyclo[L-Phenylalanyl-D-α-hydroxysovaleryl-L-leucyl-D-α-hydroxyisocaproyl]; (3S,6R,9S,12R)-3,12-Dibenzyl-6-isobutyl-9-(1-methylpropyl)-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetrone
EINECS	Contact for details

Quality Control

Our Beauveriolide I is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and structural verification via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.