Description

Ly 294002 Hydrochloride is a potent and selective cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3K), a key enzyme in the PI3K/Akt/mTOR signaling pathway. This compound is a critical research tool for studying cellular processes such as growth, proliferation, and survival, and for validating PI3K as a therapeutic target. It is essential for researchers and pharmaceutical developers in the fields of oncology, metabolic disease research, and cell biology.

Application

• Biomedical Research: A fundamental tool for inhibiting PI3K activity in cell culture and animal models to study signal transduction pathways.
• Oncology Research: Used to investigate the role of PI3K in cancer cell proliferation, survival, and tumorigenesis, supporting drug discovery efforts.
• Metabolic Disease Studies: Applied in research exploring insulin signaling, glucose homeostasis, and related metabolic disorders.
• Neurobiology: Utilized to examine the PI3K pathway's function in neuronal survival, differentiation, and synaptic plasticity.
• Cardiovascular Research: Employed in studies of cardiac hypertrophy, angiogenesis, and endothelial cell function.
• Inflammatory Response Analysis: Serves as a key reagent for dissecting the role of PI3K in immune cell activation and inflammatory pathways.
• High-Throughput Screening (HTS): Used as a reference standard or positive control in assay development and compound screening campaigns targeting the PI3K pathway.
• Mechanistic Studies: Essential for validating the specificity of new PI3K inhibitors and understanding downstream effector mechanisms.

Basic Information

Product Name	Ly 294002 Hydrochloride
CAS No.	154447-36-6
Molecular Formula	C19H17NO3 · HCl
Molecular Weight	343.80 g/mol
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride; LY-294002 HCl; LY294002 hydrochloride; 2-(4-Morpholinyl)-8-phenylchromone hydrochloride; PI3K Inhibitor LY294002 hydrochloride; 8-Phenyl-2-(morpholin-4-yl)chromen-4-one hydrochloride
EINECS	Contact for details

Quality Control

Our Ly 294002 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring the material meets the stringent specifications required for reproducible research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.