Description

2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in advanced organic synthesis. Its value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the sterically hindered pentamethyldihydrobenzofuran sulfonyl group to create novel compounds with tailored properties. This high-purity building block is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting specific enzyme inhibition.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the bulky sulfonyl group can enhance biological activity and selectivity.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials that require specific sulfonated functional groups.
• Chemical Biology Probes: Serves as a reagent for labeling and modifying biomolecules to study protein function and interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical manufacturers offering bespoke synthesis services to clients in R&D.
• Sulfonamide Library Production: Facilitates high-throughput synthesis of diverse sulfonamide compounds for screening in drug discovery.

Basic Information

Product Name	2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Chloride
CAS No.	154445-78-0
Molecular Formula	C₁₅H₁₉ClO₃S
Molecular Weight	314.83 g/mol
Synonyms	5-(Chlorosulfonyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran; 2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuransulfonyl chloride; Pentamethyl dihydrobenzofuran sulfonyl chloride; 154445-78-0; 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl Chloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements of pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.