Description

Clasto-Lactacystin β-Lactone is a highly specific and potent proteasome inhibitor, representing the active form of the natural product lactacystin. This compound is critical for researchers investigating the ubiquitin-proteasome pathway, a fundamental regulatory system for protein degradation in cells. It is an essential biochemical tool for pharmaceutical R&D, biotechnology, and academic laboratories focused on cancer research, neurodegenerative diseases, and cellular signaling mechanisms.

Application

• Biochemical Research: A primary tool for selectively inhibiting the 20S proteasome's chymotrypsin-like activity, used to study protein turnover, cell cycle regulation, and apoptosis.
• Pharmaceutical Development: Serves as a reference standard and a key pharmacophore in the development of novel proteasome-targeting therapeutics for oncology and inflammatory diseases.
• Cell Biology Studies: Used to elucidate the role of the proteasome in various cellular processes, including antigen presentation, stress response, and signal transduction pathways.
• Neuroscience Research: Applied in models of neurodegenerative disorders (e.g., Alzheimer's, Parkinson's) to understand the accumulation of misfolded proteins and proteasomal dysfunction.
• Mechanism of Action Studies: Employed to validate the specificity of drug candidates and to map biochemical pathways dependent on proteasomal activity.

Basic Information

Product Name	Clasto-Lactacystin β-Lactone
CAS No.	154226-60-5
Molecular Formula	C15H24N2O7S
Molecular Weight	376.43 g/mol
Synonyms	Clasto-Lactacystin β-Lactone; (2S,3R)-3-Hydroxy-2-[(2S)-2-hydroxy-2-methyl-4-(methylsulfanyl)butanoyl]amino]-4-methylpentanoic acid β-lactone; Lactacystin β-Lactone; Omuralide; Proteasome Inhibitor I; MG-132 analog (active form); NSC 332200
EINECS	Contact for details

Quality Control

Our Clasto-Lactacystin β-Lactone is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality guidelines to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.