Description

Caged Ca2+ Channel Antagonist CAS NO 154026-67-2 is a photolabile, biologically inactive precursor of a calcium channel blocker. This compound is critically important for researchers requiring precise, spatiotemporal control over calcium signaling in cellular and physiological studies. It is primarily needed by scientists in neuroscience, cardiovascular research, and cell biology for advanced photolysis experiments.

Application

• Photopharmacology Research: Enables light-triggered, localized inhibition of voltage-gated calcium channels (VGCCs) to study channel function and downstream signaling pathways with high temporal and spatial resolution.
• Neuroscience Studies: Used to investigate the role of calcium influx in neurotransmitter release, synaptic plasticity, and neuronal excitability by uncaging the antagonist with UV light at specific synapses or cells.
• Cardiovascular Physiology: Applied in research on cardiac muscle contraction and pacemaker activity, allowing researchers to precisely block calcium channels in isolated cardiomyocytes or tissue sections.
• Cellular Calcium Imaging: Serves as a critical tool in conjunction with calcium indicators (e.g., Fura-2, Fluo-4) to manipulate intracellular calcium levels and calibrate imaging systems.
• Drug Discovery Screening: Utilized in high-content screening assays to validate calcium channel targets and evaluate the effects of novel therapeutic compounds in a controlled manner.
• Developmental Biology: Facilitates studies on calcium's role in processes like fertilization, cell division, and differentiation through targeted, light-induced inhibition.

Basic Information

Item	Detail
Product Name	Caged Ca2+ Channel Antagonist
CAS No.	154026-67-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nitrophenyl-EGTA-Amino Acid Conjugate; Caged Calcium Channel Blocker; Photocaged Ca2+ Antagonist; DM-Nitrophen Ca2+ Channel Inhibitor Precursor; Light-sensitive Ca2+ Channel Antagonist; NP-EGTA based Ca2+ Channel Inhibitor; UV-uncageable Calcium Antagonist
EINECS	Contact for details

Quality Control

Our Caged Ca2+ Channel Antagonist is produced and handled under strict quality protocols to ensure the integrity and performance critical for sensitive research applications. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and confirmation of structure and photolytic properties. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Photolytic Efficiency	Contact for details
Solubility	Soluble in DMSO, aqueous buffer (upon formulation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.