Description

Axinastatin 2 is a potent, synthetic cyclic depsipeptide compound designed to mimic natural marine sponge metabolites. This compound is valued for its significant biological activity, particularly as a selective inhibitor of matrix metalloproteinases (MMPs), which are key enzymes involved in tissue remodeling and disease progression. It serves as a critical research tool for scientists in pharmaceutical development, oncology research, and biochemistry, enabling the study of cellular invasion, angiogenesis, and metastasis.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of novel anti-cancer and anti-metastatic therapies.
• Biochemical Assay Development: Serves as a potent, selective inhibitor in enzymatic assays to study the activity and inhibition kinetics of MMP-2 and MMP-9 (Gelatinase A and B).
• Cancer Biology Studies: Employed in in vitro and in vivo models to investigate tumor cell invasion, angiogenesis, and the role of extracellular matrix degradation in metastasis.
• Academic Research: A key compound for universities and research institutes exploring protease biology, signal transduction pathways, and marine natural product pharmacology.
• Preclinical Drug Candidate: Acts as a lead compound for the structural optimization and development of next-generation MMP inhibitors with improved pharmacokinetic profiles.

Basic Information

Product Name	Axinastatin 2
CAS No.	153723-34-3
Molecular Formula	C34H49N7O9
Molecular Weight	699.80 g/mol
Synonyms	Axinastatin 2; Cyclo[(2S,3R)-3-hydroxy-2-methylpentanoyl-L-valyl-N-methyl-L-isoleucyl-L-leucyl-(3S)-3-amino-6-hydroxy-7-methyloctanoyl-L-valyl-N-methyl-L-isoleucyl-L-leucyl]; MMP Inhibitor II; MMP-2/MMP-9 Inhibitor; Marine Cyclic Depsipeptide; Batimastat Analog
EINECS	Contact for details

Quality Control

Our Axinastatin 2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.