Description

Tyrphostin Ag 1112 CAS NO 153150-84-6 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, belonging to the tyrphostin class of compounds. This specificity makes it a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for biochemical and pharmacological studies.

Application

• Biomedical Research: A key reagent for investigating EGFR-mediated signaling cascades in cancer biology and cell biology studies.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and target validation for oncology therapeutics.
• Academic Research: Employed in university and institutional labs for fundamental research on tyrosine kinase inhibitors and their mechanisms of action.
• Signal Transduction Studies: Essential for dissecting the role of EGFR in various cellular processes and disease models.
• Biochemical Assay Development: Serves as a control compound in developing and optimizing kinase inhibition assays.

Basic Information

Product Name	Tyrphostin Ag 1112
CAS No.	153150-84-6
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 1112; Tyrphostin AG 1112; 4-Hydroxy-3,5-dimethoxybenzylidene malononitrile; EGFR Tyrosine Kinase Inhibitor AG1112; 2-[(3,5-Dimethoxy-4-hydroxyphenyl)methylene]propanedinitrile; (E)-2-(3,5-Dimethoxy-4-hydroxybenzylidene)malononitrile; NSC 693646
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 1112 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.