Description

Z-Asp(Otbu)-Bromomethylketone is a specialized, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of protease inhibitors and other biologically active peptides, enabling precise molecular construction. Pharmaceutical researchers and fine chemical manufacturers need it for developing new therapeutic agents, particularly in the fields of virology and oncology, where high-purity intermediates are non-negotiable.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of protease inhibitors, including HIV-1 protease inhibitors and renin inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate specific aspartic acid derivatives with a protected side chain.
• Bioconjugation & Probe Development: Serves as a reactive handle for creating activity-based probes (ABPs) to study enzyme activity and mechanism.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop novel drug candidates targeting various enzymes.
• Chemical Biology Tool: Utilized for the design and synthesis of irreversible enzyme inhibitors for target validation.
• Fine Chemical Production: An important building block for custom synthesis services catering to the life sciences industry.

Basic Information

Product Name	Z-Asp(Otbu)-Bromomethylketone
CAS No.	153088-76-7
Molecular Formula	C17H22BrNO6
Molecular Weight	416.27 g/mol
Synonyms	N-Carbobenzoxy-L-aspartic acid β-tert-butyl ester α-bromomethyl ketone; Z-L-Aspartic acid β-tert-butyl ester α-bromomethyl ketone; Z-Asp(OtBu)-CH2Br; Benzyl N-[(2S)-1-(bromoacetyl)-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate; (2S)-2-{[(Benzyloxy)carbonyl]amino}-4-[(2-methylpropan-2-yl)oxy]-4-oxobutyl bromomethyl ketone; Z-Asp(OBzl)-Bromomethylketone (common alternate); Boc-Asp(OtBu)-Bromomethylketone (related protected form)
EINECS	Contact for details

Quality Control

Our Z-Asp(Otbu)-Bromomethylketone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP-grade pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines, and our quality systems support compliance for customers operating under FDA and EMA regulations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.