Description

3-Fluoro-2-Iodopyridine-4-Carboxylic Acid is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and a carboxylic acid group on the pyridine ring, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl systems.
• Derivatization for SAR Studies: The carboxylic acid group allows for easy amide or ester formation, facilitating structure-activity relationship (SAR) studies in drug discovery.

Basic Information

Item	Details
Product Name	3-Fluoro-2-Iodopyridine-4-Carboxylic Acid
CAS No.	153035-09-7
Molecular Formula	C6H3FINO2
Molecular Weight	266.99 g/mol
Synonyms	4-Pyridinecarboxylic acid, 3-fluoro-2-iodo-; 2-Iodo-3-fluoropyridine-4-carboxylic acid; 3-Fluoro-2-iodoisonicotinic acid; 3-Fluoro-2-iodopyridine-4-carboxylic acid; 153035-09-7; 3-Fluoro-2-iodo-4-pyridinecarboxylic acid; 2-Iodo-3-fluoro-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-Iodopyridine-4-Carboxylic Acid is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.