Description

2-Fluoro-4-Iodo-5-Picoline is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, offers versatile reactivity for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated heterocycles.
• Material Science Research: Used in the creation of advanced organic electronic materials, ligands for catalysis, and liquid crystals.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a radiolabeling precursor.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex target molecules.

Basic Information

Item	Details
Product Name	2-Fluoro-4-Iodo-5-Picoline
CAS No.	153034-94-7
Molecular Formula	C6H5FIN
Molecular Weight	237.02 g/mol
Synonyms	4-Iodo-2-fluoro-5-methylpyridine; 5-Methyl-2-fluoro-4-iodopyridine; 2-Fluoro-4-iodo-5-methylpyridine; 2-Fluoro-4-iodo-5-picoline; 153034-94-7; 4-Iodo-2-fluoro-5-picoline; 5-Picoline, 2-fluoro-4-iodo-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Iodo-5-Picoline is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency. Our standard quality commitment includes HPLC purity ≥98% (with higher grades available), identity confirmation by FT-IR and NMR, and stringent control of related substances. A detailed Certificate of Analysis (COA) is supplied with each shipment, and we support audits and regulatory submissions for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.