Description

Cortisol 21-Sulfate Potassium Salt is a key sulfated metabolite of the endogenous glucocorticoid hormone cortisol. This compound is of significant value as a high-purity reference standard and a critical biochemical reagent for research and diagnostic applications. It is primarily needed by pharmaceutical R&D laboratories, clinical diagnostics manufacturers, and academic institutions conducting studies in endocrinology, metabolism, and stress response.

Application

• Biochemical Research: Used as a precise reference standard in the study of cortisol metabolism and sulfotransferase enzyme activity.
• Clinical Diagnostics: Serves as a critical calibrator and control material in the development and validation of immunoassays (e.g., ELISA, LC-MS/MS) for measuring cortisol sulfate levels in biological samples.
• Pharmaceutical Development: Employed in pharmacokinetic and metabolic stability studies for drug candidates that interact with the glucocorticoid pathway.
• Endocrinology Studies: Essential for investigating the role of sulfated steroid hormones in various physiological and pathological conditions.
• Quality Control: Acts as a system suitability standard in analytical laboratories to ensure the accuracy and precision of chromatographic methods.

Basic Information

Product Name	Cortisol 21-Sulfate Potassium Salt
CAS No.	152957-32-9
Molecular Formula	C21H29KO8S
Molecular Weight	504.61 g/mol
Synonyms	Hydrocortisone 21-Sulfate Potassium Salt; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(Hydrogen Sulfate) Potassium Salt; Cortisol 21-Hydrogen Sulfate Potassium Salt; 21-Sulfocortisol Potassium Salt; Reichstein's Substance S 21-Sulfate Potassium Salt; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(Hydrogen Sulfate) Potassium Salt
EINECS	Contact for details

Quality Control

Our Cortisol 21-Sulfate Potassium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (IR, NMR), to ensure it meets the high standards required for research and diagnostic use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.