Description

3-Carboxy Mefenamic Acid Acyl-B-D-Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) mefenamic acid. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in bioanalytical method development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of mefenamic acid and its metabolites in biological matrices during clinical and pre-clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to investigate the metabolic pathways, excretion profiles, and bioavailability of mefenamic acid.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and toxicology studies.
• Impurity Profiling: Acts as a known impurity or degradation product standard for quality control in mefenamic acid drug substance and finished product manufacturing.
• Regulatory Submissions: Provides critical data for regulatory filings (e.g., with the FDA, EMA) to demonstrate understanding of a drug's metabolic fate.

Basic Information

Product Name	3-Carboxy Mefenamic Acid Acyl-B-D-Glucuronide
CAS No.	152832-30-9
Molecular Formula	C23H23NO9
Molecular Weight	457.43 g/mol
Synonyms	3'-Carboxymefenamic Acid Acyl Glucuronide; 3'-Carboxy Mefenamic Acid Glucuronide; Mefenamic Acid 3-Carboxy Metabolite Glucuronide; 2-[[3-(Carboxymethyl)phenyl]amino]benzoic acid 1-(β-D-Glucopyranuronosyl) ester; 3'-Hydroxymethyl Mefenamic Acid Glucuronide (related metabolite); 3-CMAA-Gluc; Mefenamic Acid Metabolite Glucuronide; 3-Carboxy Mefenamic Acid β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our 3-Carboxy Mefenamic Acid Acyl-B-D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference material applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.