Description

Seco-Duocarmycin Sa is a potent synthetic derivative of the duocarmycin family of antitumor antibiotics, known for its sequence-selective DNA alkylation properties. This compound is a critical advanced intermediate in the research and development of novel antibody-drug conjugates (ADCs) and targeted cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and preclinical studies.

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as a key cytotoxic warhead precursor for constructing next-generation ADCs targeting specific cancer cell antigens.
• Oncology Research & Drug Discovery: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel chemotherapeutic agents.
• Mechanistic Studies: Employed in biochemical research to study DNA minor groove binding and alkylation mechanisms for understanding cytotoxicity.
• Preclinical Development: Integral in formulating and testing new drug candidates in in vitro and in vivo models to evaluate efficacy and safety profiles.
• Process Chemistry & Scale-Up: Used as a benchmark in optimizing synthetic routes and manufacturing processes for potent cytotoxins under controlled GMP-like environments.

Basic Information

Product Name	Seco-Duocarmycin Sa
CAS No.	152785-82-5
Molecular Formula	C31H38N4O7
Molecular Weight	578.66 g/mol
Synonyms	Duocarmycin SA Seco-analog; Seco-Duocarmycin SA; (1S,8S,14S,20S)-14-[(Cyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-yl)carbonyl]-1,20-dimethyl-9,22-dioxa-4,12,17-triazatetracyclo[14.7.1.03,8.013,18]tetracosa-3,5,7,13,15,17,19-heptaene-2,10,16,23-tetrone; CC-1065 Seco-Analog; (+)-Seco-Duocarmycin SA; NSC-D 700149
EINECS	Contact for details

Quality Control

Every batch of Seco-Duocarmycin Sa is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your regulatory and research requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and strength as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.