Description

Epothilone B is a potent, naturally occurring microtubule-stabilizing macrolide with significant antitumor activity. Its unique mechanism of action, which involves stabilizing cellular microtubules and inducing mitotic arrest, makes it a compound of high interest in oncology research and drug development. This product is essential for pharmaceutical R&D teams, medicinal chemists, and academic researchers focused on developing novel cancer therapeutics and studying tubulin biology.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for the quality control and validation of related drug substances and formulations in development.
• Oncology Research: Used as a key biochemical tool to study mechanisms of apoptosis, cell cycle arrest, and resistance pathways in various cancer cell lines.
• Medicinal Chemistry & Drug Discovery: Acts as a lead compound and a crucial intermediate for the synthesis and structure-activity relationship (SAR) study of novel epothilone analogs and next-generation chemotherapeutic agents.
• Biochemical Assays: Employed in in vitro tubulin polymerization assays to evaluate and compare the potency of microtubule-targeting agents.
• Academic & Preclinical Studies: Utilized in university and institutional labs for fundamental research on cytoskeleton dynamics and for evaluating efficacy in animal models of cancer.

Basic Information

Product Name	Epothilone B
CAS No.	152044-54-7
Molecular Formula	C27H41NO6S
Molecular Weight	507.68 g/mol
Synonyms	Epothilone B; Patupilone; EPO906; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; 4,17-Dioxabicyclo[14.1.0]heptadecane, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-; (-)-Epothilone B
EINECS	Contact for details

Quality Control

Our Epothilone B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research and development with material that meets the stringent requirements for pharmaceutical reference standards and advanced biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.