Description

Epothilone A is a potent, naturally occurring macrolide compound that functions as a microtubule-stabilizing agent. Its primary commercial and research significance lies in its role as a lead compound and a crucial reference standard in the development of novel anti-cancer therapeutics. This product is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on oncology drug discovery and mechanism-of-action studies. Epothilone A serves as a key biochemical tool for studying tubulin polymerization and evaluating next-generation chemotherapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for the quality control and validation of Epothilone-based drug substances and products.
• Oncology Research & Drug Discovery: Used as a lead compound and biological probe in high-throughput screening and structure-activity relationship (SAR) studies for novel anti-mitotic agents.
• Biochemical Mechanism Studies: Employed in cell biology and pharmacology research to investigate microtubule dynamics, cell cycle arrest, and apoptosis pathways.
• Preclinical Development: Utilized in *in vitro* and *in vivo* studies to model efficacy, pharmacokinetics, and toxicity profiles of microtubule-targeting therapies.
• Academic Research: A critical reagent for universities and research institutes studying cancer biology, chemical biology, and natural product synthesis.

Basic Information

Product Name	Epothilone A
CAS No.	152044-53-6
Molecular Formula	C26H39NO6S
Molecular Weight	493.66 g/mol
Synonyms	(-)-Epothilone A; Epothilone A, (-)-; 4,17-Didehydro-17-oxo-6-deoxy-6-(2-methyl-4-thiazolyl)-epothilone B; 6-Desmethoxy-12,13-desoxyepothilone B; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-4-thiazolyl)prop-1-en-1-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
EINECS	Contact for details

Quality Control

Our Epothilone A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity standards suitable for pharmaceutical research, with typical purity levels exceeding 95% (HPLC). Certificates of Analysis are available upon request for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and potency. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.