Description

Pyripyropene D is a potent and specific inhibitor of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol esterification and absorption. This compound is of significant interest for its potential in lipid metabolism research and as a lead structure in the development of novel therapeutic agents targeting atherosclerosis and hypercholesterolemia. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, metabolic disorders, and enzyme inhibition studies.

Application

• Pharmaceutical Research & Development: Serves as a key biochemical tool and lead compound for developing new ACAT inhibitors to manage cholesterol levels.
• Mechanistic Studies in Lipid Metabolism: Used to investigate the ACAT enzyme's role in intracellular cholesterol esterification and foam cell formation, relevant to atherosclerosis.
• In Vitro & Cell-Based Assays: Employed in high-throughput screening and validation assays to study ACAT activity and identify new modulators.
• Academic Research: A critical reagent for universities and research institutes studying cardiovascular biology, metabolic pathways, and enzyme kinetics.
• Preclinical Development: Evaluated in animal models to assess the efficacy and pharmacokinetics of ACAT inhibition for potential therapeutic applications.

Basic Information

Product Name	Pyripyropene D
CAS No.	151519-46-9
Molecular Formula	C32H35NO11
Molecular Weight	609.62 g/mol
Synonyms	Pyripyropene D; ACAT Inhibitor Pyripyropene D; (3S,4aR,5'S,6'S,6aR,10aR,10bS)-5',6',10,10b-Tetrahydro-3,4a,7-trimethyl-3H-spiro[naphtho[2,1-b]pyran-2,2'-pyrano[3,2-b]pyran]-5,8-dione 6'-acetate 11-(3-methyl-2-butenoate); Mer-A2026D; ACAT inhibitor A.
EINECS	Contact for details

Quality Control

Our Pyripyropene D is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.