Description

Pyripyropene C is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme critical in cholesterol esterification and absorption. This makes it a valuable research tool for studying lipid metabolism and a promising lead compound for the development of novel therapeutic agents targeting atherosclerosis and related metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular and metabolic disease research.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmacological tool for investigating ACAT inhibition mechanisms and validating drug discovery assays.
• Biochemical Studies: For in vitro and cellular studies to elucidate the role of ACAT in cholesterol homeostasis, foam cell formation, and atherogenesis.
• Lead Compound Optimization: Serving as a structural scaffold for medicinal chemistry programs aimed at developing improved ACAT inhibitors with enhanced potency and selectivity.
• Academic Research: Used in university and institutional labs for fundamental research into lipid biology, cardiovascular disease pathways, and metabolic syndrome.
• Preclinical Evaluation: Employed in animal model studies to assess the efficacy and pharmacokinetics of ACAT-targeting therapeutic strategies.

Basic Information

Item	Detail
Product Name	Pyripyropene C
CAS No.	151519-45-8
Molecular Formula	C31H35NO11
Molecular Weight	597.61 g/mol
Synonyms	Pyripyropene C; 151519-45-8; ACAT Inhibitor Pyripyropene C; (3S,4aR,5R,6S,8aR)-5-[(2S,3S,4S,5S,6R)-4,5-Dihydroxy-3,6-dimethyloxan-2-yl]oxy-6-hydroxy-8a-methyl-3-[(E)-2-methylbut-2-enoyl]oxy-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-carboxylic acid; (E)-Pyripyropene C; Pyripyropene derivative C
EINECS	Contact for details

Quality Control

Our Pyripyropene C is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.