Description

Bafilomycin CAS NO 151499-39-7 is a potent and highly specific macrolide antibiotic that functions as a vacuolar-type H+-ATPase (V-ATPase) inhibitor. This compound is a critical research tool for studying intracellular vesicle trafficking, autophagy, and lysosomal function. It is essential for researchers and developers in the fields of cell biology, pharmacology, and biochemistry who require a reliable, high-purity reagent for mechanistic studies and assay development.

Application

• Biochemical Research: As a selective inhibitor of V-ATPase to study lysosomal acidification, autophagy, and endocytosis pathways.
• Pharmacology & Drug Discovery: Used in target validation and screening assays for diseases related to lysosomal dysfunction, such as cancer and neurodegenerative disorders.
• Cell Biology Studies: Essential for investigating intracellular pH regulation, organelle function, and membrane transport processes.
• Antibiotic Research: Serves as a reference standard and active compound in studies of macrolide antibiotics and their mechanisms of action.
• Academic & Industrial R&D: A key reagent in university laboratories, contract research organizations (CROs), and biopharmaceutical companies for fundamental and applied research.

Basic Information

Product Name	Bafilomycin
CAS No.	151499-39-7
Molecular Formula	C35H58O9
Molecular Weight	622.83 g/mol
Synonyms	Bafilomycin A1; Bafilomycin A1 from *Streptomyces griseus*; BafA1; V-ATPase Inhibitor, Bafilomycin A1; NSC 381509; 4,10-Dihydroxy-15-[(1S,2S,4R,6R,7S,8S,9R,11S,12S,13R,15S,17R)-1,6,8,11,13,15-hexamethyl-2,7,9,12,16,18-hexaoxapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁴,¹⁸]icosan-17-yl]-5-methoxy-3,13-dimethyloxacyclopentadec-13-ene-2,6,14-trione
EINECS	Contact for details

Quality Control

Our Bafilomycin is produced under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, potency, and related substances is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity (V-ATPase Inhibition)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.