Description

1-Ethynyl-3,5-Difluorobenzene 97 is a high-purity fluorinated aromatic building block featuring an ethynyl functional group. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides that require fluorinated aromatic components for enhanced bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: Employed in academic and industrial R&D for Sonogashira coupling, click chemistry, and other palladium-catalyzed reactions to create novel conjugated systems.
• Ligand and Catalyst Development: Useful for constructing sophisticated ligand frameworks in coordination chemistry and catalysis.

Basic Information

Product Name	1-Ethynyl-3,5-Difluorobenzene 97
CAS No.	151361-87-4
Molecular Formula	C8H4F2
Molecular Weight	138.12 g/mol
Synonyms	3,5-Difluoroethynylbenzene; 3,5-Difluorophenylacetylene; 1-Ethynyl-3,5-difluorobenzene; 3,5-Difluoro-1-ethynylbenzene; (3,5-Difluorophenyl)ethyne; Ethynyl-3,5-difluorobenzene; 3,5-Difluorobenzeneacetylene
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-3,5-Difluorobenzene 97 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure it meets the specified purity and identity criteria. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture ingress and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.