Description

Ro-32-0432 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC) isoforms, particularly PKCα, βI, βII, and γ. This high-purity biochemical tool is critical for elucidating PKC-mediated signaling pathways in cellular and molecular biology research. It is essential for researchers and pharmaceutical developers in the fields of neuroscience, oncology, and cardiovascular disease, where precise modulation of PKC activity is required for target validation and mechanistic studies.

Application

• Biochemical Research: A key tool compound for studying the role of Protein Kinase C (PKC) in signal transduction, cell proliferation, and differentiation.
• Neuroscience Studies: Used to investigate PKC's function in neuronal plasticity, neurotransmitter release, and models of neurological disorders.
• Oncology Research: Employed in cancer research to explore PKC isoform-specific roles in tumor progression, metastasis, and apoptosis.
• Cardiovascular Research: Applied in studies of cardiac hypertrophy, vascular smooth muscle contraction, and endothelial function.
• Inflammatory Pathway Analysis: Utilized to dissect PKC's involvement in immune cell activation and inflammatory responses.
• Pharmaceutical Development: Serves as a reference standard and pharmacological probe in drug discovery programs targeting PKC.

Basic Information

Product Name	Ro-32-0432
CAS No.	151342-35-7
Molecular Formula	C24H24N4O4
Molecular Weight	432.47 g/mol
Synonyms	Ro 32-0432; Ro-32-0432; Ro320432; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Bisindolylmaleimide IX; Protein Kinase C Inhibitor, Ro-32-0432; PKC Inhibitor Ro-32-0432
EINECS	Contact for details

Quality Control

Our Ro-32-0432 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.