Description

4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to act as a sulfonylation reagent, introducing the robust sulfonyl functional group to create novel compounds with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Precursor for functional polymers, dyes, and liquid crystals where the sulfonyl group modifies thermal stability and solubility.
• Chemical Research: A valuable reagent in medicinal chemistry and process development for introducing sulfonyl moieties in complex molecules.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride
CAS No.	151258-36-5
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.64 g/mol
Synonyms	4-Methyl-3-(trifluoromethyl)benzenesulfonyl chloride; 3-Trifluoromethyl-4-methylbenzenesulfonyl chloride; α,α,α-Trifluoro-4-methyl-m-toluenesulfonyl chloride; 2-Methyl-α,α,α-trifluoro-m-toluenesulfonyl chloride; 4-Methyl-α,α,α-trifluoro-m-toluenesulfonyl chloride; 3-(Trifluoromethyl)-4-methylbenzenesulfonyl chloride; 4-Methyl-3-trifluoromethylbenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.