Description

4-(Difluoromethoxy)-3-(Cyclopropylmethoxy)-Benzaldehyde CAS NO 151103-09-2 is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzaldehyde core substituted with difluoromethoxy and cyclopropylmethoxy groups. This compound is a critical building block in modern medicinal chemistry, valued for its role in synthesizing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of next-generation therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy group can impart favorable biological activity and environmental persistence.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• API Manufacturing: Employed in the multi-step synthesis of complex target molecules for clinical trial materials and commercial API production under GMP guidelines.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Difluoromethoxy)-3-(Cyclopropylmethoxy)-Benzaldehyde
CAS No.	151103-09-2
Molecular Formula	C12H12F2O3
Molecular Weight	242.22 g/mol
Synonyms	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde; 4-(Difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde; Benzaldehyde, 4-(difluoromethoxy)-3-(cyclopropylmethoxy)-; 151103-09-2; 3-Cyclopropylmethoxy-4-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-(Cyclopropylmethoxy)-Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the material should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.