Description

4-Difluoromethoxy-3-Hydroxybenzaldehyde is a high-purity, multi-functional aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and phenolic hydroxyl substituents make it a valuable precursor for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Advanced Polymer Monomer: Employed in the creation of specialty polymers with specific thermal, chemical, or optical properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination chemistry and heterocyclic compound synthesis.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	4-Difluoromethoxy-3-Hydroxybenzaldehyde
CAS No.	151103-08-1
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	3-Hydroxy-4-(difluoromethoxy)benzaldehyde; 4-(Difluoromethoxy)-3-hydroxybenzaldehyde; 3-Hydroxy-4-difluoromethoxybenzaldehyde; Benzaldehyde, 3-hydroxy-4-(difluoromethoxy)-; 151103-08-1; Aldehyde, 3-hydroxy-4-difluoromethoxybenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethoxy-3-Hydroxybenzaldehyde is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to ensure consistency and suitability for your synthetic applications. Our quality standards are designed to meet the rigorous demands of pharmaceutical and fine chemical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider an inert atmosphere. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.