Description

7-Epi-Cephalomannine is a structurally significant taxane derivative, closely related to paclitaxel and cephalomannine, known for its potent biological activity. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development, particularly in the field of oncology. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel chemotherapeutic agents and studying structure-activity relationships of taxane-based drugs.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Oncology Research: Serves as a key intermediate and biological probe in the research and development of next-generation anti-cancer therapeutics, particularly microtubule-stabilizing agents.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway studies of taxane-based chemotherapy drugs.
• Process Chemistry: Acts as a critical intermediate in the semi-synthetic production pathways of complex taxane pharmaceuticals.
• Academic & Institutional Research: Utilized in university and institutional labs for biochemical, pharmacological, and medicinal chemistry studies.
• Impurity Profiling: Essential for the identification and quantification of process-related impurities and degradants in paclitaxel and related drug substances.

Basic Information

Product Name	7-Epi-Cephalomannine
CAS No.	150547-36-7
Molecular Formula	C45H53NO14
Molecular Weight	831.91 g/mol
Synonyms	7-Epi-Cephalomannine; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate; 7-Epicephalomannine; Cephalomannine, 7-epi-; 7-Epi-cephalomannine
EINECS	Contact for details

Quality Control

Our 7-Epi-Cephalomannine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.