Description

20-Demethoxy-20-(3-(((5-Dimethylamino)Naphthalen-1-Yl)Sulfonyl)Amino)Propylmaytansinol-3-Isobutyrate is a highly specialized synthetic derivative of the potent cytotoxic agent maytansine, engineered for targeted therapeutic applications. This compound is a critical intermediate in the development of Antibody-Drug Conjugates (ADCs), where it serves as the potent cytotoxic payload. It is essential for pharmaceutical R&D teams and manufacturers focused on creating next-generation oncology treatments, particularly for solid tumors and hematological malignancies.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): The core application is as the cytotoxic warhead in ADCs, where it is conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research & Development: Used as a key reference standard and building block in preclinical and clinical research for novel targeted chemotherapeutics.
• Bioconjugation Chemistry Studies: Serves as a model compound for developing and optimizing linker-payload technologies and conjugation methodologies.
• Pharmaceutical Intermediate Synthesis: Acts as a critical advanced intermediate in the multi-step synthesis of final ADC payload molecules like DM1 and DM4 analogs.
• Mechanism of Action Studies: Utilized in biochemical assays to study microtubule inhibition and apoptosis induction in cancer cell lines.

Basic Information

Product Name	20-Demethoxy-20-(3-(((5-Dimethylamino)Naphthalen-1-Yl)Sulfonyl)Amino)Propylmaytansinol-3-Isobutyrate
CAS No.	150422-35-8
Molecular Formula	C46H60N4O9S
Molecular Weight	845.06 g/mol
Synonyms	DM1-SMCC Intermediate; Maytansinoid DM1 derivative; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine precursor; Ansamitocin P-3 derivative; DM1 payload linker intermediate; mertansine precursor; Tubulin inhibitor payload; ADC cytotoxic agent 150422-35-8
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is manufactured under strict quality systems. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for ADC development. Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques including HPLC, LC-MS, and NMR. Our quality commitment aligns with cGMP principles for APIs and advanced intermediates, ensuring traceability and reliability for critical research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store in a dedicated, secure facility away from unauthorized personnel.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.