Description

Gc7 Sulfate CAS NO 150417-90-6 is a high-purity, synthetic chemical compound of significant interest in biochemical and pharmaceutical research. This material serves as a potent and selective inhibitor of eukaryotic translation initiation factor 5A (eIF5A) hypusination, a critical post-translational modification. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, virology, and cellular senescence studies. Its precise mechanism of action makes it a valuable tool for investigating protein synthesis regulation and developing novel therapeutic strategies.

Application

• Biochemical Research: Used as a key reagent to study the hypusine pathway and the role of eIF5A in mRNA translation and cell proliferation.
• Oncology Research: Investigated for its potential anti-proliferative effects in various cancer cell lines, including leukemia and solid tumors.
• Virology Studies: Applied in research to understand viral replication mechanisms, particularly for HIV-1 and other viruses dependent on host cell translation machinery.
• Neurodegeneration Research: Explored in models of age-related cognitive decline and neurodegenerative diseases linked to protein misfolding and synaptic dysfunction.
• Drug Discovery: Serves as a lead compound or pharmacological tool for validating eIF5A as a therapeutic target in high-throughput screening assays.
• Cell Senescence & Aging: Utilized to modulate cellular senescence pathways and study the impact of translation inhibition on lifespan and age-related phenotypes.

Basic Information

Product Name	Gc7 Sulfate
CAS No.	150417-90-6
Molecular Formula	C₂₀H₄₂N₁₀O₈ • xH₂SO₄
Molecular Weight	526.62 g/mol (Free base)
Synonyms	N1-Guanyl-1,7-diaminoheptane Sulfate; GC7 Sulfate; Deoxyhypusine Synthase Inhibitor GC7; eIF5A Hypusination Inhibitor; 1,7-Bis(guanyl)heptanediamine Sulfate; CNI-1493 Sulfate (related compound); Guanyl-1,7-heptanediamine Sulfate; Spermidine Analog GC7 Sulfate
EINECS	Contact for details

Quality Control

Every batch of Gc7 Sulfate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets specifications suitable for research and development purposes, with purity typically ≥95% by HPLC. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, impurities, and identity is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.