Description

17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin Hcl is a semi-synthetic derivative of the natural product geldanamycin, functioning as a potent and selective inhibitor of the Hsp90 molecular chaperone. This compound is a critical research tool for studying cellular stress response pathways, protein folding, and oncogenic signaling in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurodegenerative disease, and anti-infective drug discovery programs.

Application

• Biomedical Research: Used as a key pharmacological probe to investigate the role of Hsp90 in cancer cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of novel Hsp90-targeted therapeutic agents.
• Mechanistic Studies: Employed in cellular and biochemical assays to study client protein degradation, heat shock response, and chaperone function.
• Academic Research: Utilized in university and institutional labs for fundamental research in molecular biology, cell signaling, and proteostasis.
• Preclinical Studies: Applied in animal models to evaluate the efficacy and pharmacokinetics of Hsp90 inhibition for various disease indications.

Basic Information

Product Name	17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin Hcl
CAS No.	150270-08-9
Molecular Formula	C33H49ClN4O7
Molecular Weight	649.22 g/mol
Synonyms	17-DMAG Hydrochloride; 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin hydrochloride; Alvespimycin Hydrochloride; NSC 707545; BMS 826476; KOS-1022; 17-DMAG HCl; 17-(2-Dimethylaminoethyl)amino-17-demethoxygeldanamycin hydrochloride
EINECS	Contact for details

Quality Control

Our 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Biological Activity (Hsp90 Binding)	IC50 as per reference

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.