Description

Tigecycline Metabolite M6 (9-Aminominocycline) is a key metabolite and structural analog of the broad-spectrum glycylcycline antibiotic tigecycline. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in antibiotic development, bioanalytical method validation, and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification and identification of tigecycline and its metabolites in biological matrices during preclinical and clinical studies.
• Metabolite Research: Used in investigative studies to understand the metabolic pathways, bioavailability, and excretion profiles of tigecycline, aiding in drug safety and efficacy assessments.
• Analytical Method Development: Essential for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other bioanalytical methods in compliance with FDA, EMA, and ICH guidelines.
• Impurity Profiling: Employed as a known impurity or degradation product standard to monitor the stability and purity of tigecycline active pharmaceutical ingredient (API) and finished drug products.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides a definitive standard for correlating drug exposure with antimicrobial activity and clinical outcomes.
• Quality Control & Assurance: Used in-house by API manufacturers and finished dosage form producers to ensure batch-to-batch consistency and regulatory compliance.

Basic Information

Product Name	Tigecycline Metabolite M6 (9-Aminominocycline)
CAS No.	149934-19-0
Molecular Formula	C₂₉H₃₉N₅O₈
Molecular Weight	585.66 g/mol
Synonyms	9-Aminominocycline; (4S,4aS,5aR,12aS)-9-Amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; Tigecycline Impurity M6; Tigecycline Related Compound M6; GAR-936 Metabolite M6; Tigecycline-9-amino Metabolite
EINECS	Contact for details

Quality Control

Our Tigecycline Metabolite M6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) detailing all test results, ensuring compliance with research and pharmaceutical reference standard requirements. Our quality commitment supports your needs for reliable and traceable materials in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant use and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.