Description

Lurtotecan is a potent topoisomerase I inhibitor belonging to the camptothecin class of antineoplastic agents. This compound is a critical pharmaceutical intermediate and active ingredient in the research and development of novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology. The material is supplied with a focus on high purity and batch-to-batch consistency to support rigorous preclinical and clinical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced anticancer drug candidates and conjugates.
• Oncology Research: Used as a reference standard and active compound in in vitro and in vivo studies to investigate mechanisms of topoisomerase I inhibition.
• Drug Discovery & Development: Integral to high-throughput screening and structure-activity relationship (SAR) studies for novel chemotherapeutic agents.
• Bioconjugation Studies: Employed in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems to enhance tumor specificity.
• Analytical Standard: Used for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.
• Formulation Research: Aids in the development of stable dosage forms, including lyophilized powders and injectable solutions.

Basic Information

Product Name	Lurtotecan
CAS No.	149882-10-0
Molecular Formula	C₂₃H₂₂N₄O₄
Molecular Weight	418.45 g/mol
Synonyms	7-[(4-Methylpiperazino)methyl]-10,11-ethylenedioxy-20(S)-camptothecin; GI-147211C; Lurtotecanum; Lurtotecan (USAN); Lurtotecanum (INN-Latin); (S)-4,11-Diethyl-4-hydroxy-9-[(4-methyl-1-piperazinyl)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (19S)-19-Ethyl-19-hydroxy-17-[(4-methyl-1-piperazinyl)methyl]-10-oxa-4-azapentacyclo[11.8.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²⁰]henicosa-1(21),2,5,7,9,11,13,15(20)-octaene-3,14-dione
EINECS	Contact for details

Quality Control

Our Lurtotecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting the stringent requirements for pharmaceutical research. Specifications typically align with high-purity reference standard grades. A detailed Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.