Description

Val-Boro-Pro is a potent and selective proteasome inhibitor, widely recognized in biochemical and pharmaceutical research. This compound is a critical tool for studying proteasome function, apoptosis, and intracellular protein degradation pathways. It is essential for researchers and developers in the fields of oncology, immunology, and neurodegenerative disease research, where precise modulation of proteasomal activity is required.

Application

• Biochemical Research: A key reagent for studying the mechanism and inhibition of the 20S proteasome complex in vitro.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening assays for novel anti-cancer and anti-inflammatory therapeutics.
• Oncology Research: Employed to investigate the role of proteasome inhibition in inducing apoptosis and controlling tumor cell proliferation.
• Immunology Studies: Applied in research on antigen presentation and immune response modulation via the ubiquitin-proteasome pathway.
• Neuroscience Research: Utilized in models studying protein aggregation diseases such as Alzheimer's and Parkinson's.
• Cell Signaling Pathways: A probe for dissecting the impact of proteasomal degradation on various signaling cascades and transcription factor regulation.

Basic Information

Product Name	Val-Boro-Pro
CAS No.	149682-77-9
Molecular Formula	C16H25BN4O4
Molecular Weight	348.21 g/mol
Synonyms	Bortezomib Boronic Acid Analogue; PS-341; [(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-[(pyrazinylcarbonyl)amino]propanoyl]amino]butyl]boronic Acid; MLN-341; LDP-341; Velcade® (Bortezomib) analogue; Proteasome Inhibitor I
EINECS	Contact for details

Quality Control

Our Val-Boro-Pro is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for high-purity biochemical reagents to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.