Description

Disprocynium 24 is a potent and selective inhibitor of organic cation transporters (OCTs), particularly OCT1, OCT2, and OCT3. This compound is a critical research tool for studying the pharmacokinetics, drug-drug interactions, and physiological roles of polyspecific cation transporters. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) focused on drug discovery, development, and transporter biology.

Application

• Pharmacological Research: Used as a reference standard and probe inhibitor to characterize the function and inhibition of organic cation transporters (OCTs) in in vitro and ex vivo assays.
• Drug-Drug Interaction (DDI) Studies: Essential for assessing the potential of new chemical entities to inhibit OCT-mediated uptake, a key component of regulatory safety pharmacology.
• Transporter Mechanism Studies: Employed to elucidate the substrate specificity and transport mechanisms of OCT1, OCT2, and OCT3 in cellular and membrane models.
• Neuropharmacology: Investigated for its effects on extraneuronal monoamine transport, relevant to studies on mood, stress, and cardiovascular function.
• Preclinical Development: Supports the interpretation of pharmacokinetic data by helping to identify transporter-mediated clearance and distribution pathways.

Basic Information

Product Name	Disprocynium 24
CAS No.	149578-82-5
Molecular Formula	C20H24N2O2
Molecular Weight	324.42 g/mol
Synonyms	1,1'-(1,4-Phenylenebis(methylene))bis(1,2,3,4-tetrahydroisoquinoline); Disprocynium 24; D22; D-22; BIC; 1,1'-[1,4-Phenylenebis(methylene)]bis(1,2,3,4-tetrahydroisoquinoline); NSC 339579; 1,1'-(1,4-Phenylenedimethylene)bis(1,2,3,4-tetrahydroisoquinoline)
EINECS	Contact for details

Quality Control

Our Disprocynium 24 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.