Description

Cgp 55845 is a high-purity, non-competitive antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). This compound is a critical research tool for investigating glutamatergic signaling pathways in the central nervous system. It is primarily utilized by pharmaceutical R&D teams and academic researchers in neuroscience for studying synaptic plasticity, neurological disorders, and potential therapeutic targets.

Application

• Neuroscience Research: Fundamental studies on glutamatergic transmission and receptor function.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening assays for mGluR5-targeted therapeutics.
• Neuropharmacology: Investigation of mGluR5's role in conditions such as anxiety, depression, Fragile X syndrome, and Parkinson's disease.
• Biochemical Assays: In vitro characterization of receptor-ligand interactions and signal transduction mechanisms.
• Academic & Institutional Labs: A key reagent for graduate and post-doctoral research projects in molecular neuroscience.

Basic Information

Product Name	Cgp 55845
CAS No.	149184-22-5
Molecular Formula	C15H12N4O4
Molecular Weight	312.28 g/mol
Synonyms	(RS)-α-Cyclopropyl-4-phosphonophenylglycine; (RS)-CPPG; CPPG; CGP-55845; CGP 55845A; mGluR5 antagonist; Metabotropic glutamate receptor 5 antagonist; α-Cyclopropyl-4-phosphonophenylglycine
EINECS	Contact for details

Quality Control

Our Cgp 55845 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request to support your research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.