Description

9-Desmethyl Tetrabenazine is a key pharmaceutical intermediate and active metabolite of the drug Tetrabenazine. This compound matters for its critical role in the synthesis and development of treatments for hyperkinetic movement disorders. It is primarily needed by pharmaceutical manufacturers and research organizations engaged in the development of central nervous system (CNS) therapeutics and advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Tetrabenazine and its related analogs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for novel CNS-targeting therapeutics.
• Metabolite Reference Standard: Serves as an analytical standard in pharmacokinetic and bioequivalence studies for Tetrabenazine.
• Neurological Disorder Research: Employed in preclinical research for investigating vesicular monoamine transporter 2 (VMAT2) inhibitors.
• Process Chemistry & Scale-up: Utilized in optimizing synthetic routes and scaling up production for pharmaceutical actives.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	9-Desmethyl Tetrabenazine
CAS No.	149183-89-1
Molecular Formula	C18H21NO2
Molecular Weight	283.37 g/mol
Synonyms	9-Desmethyltetrabenazine; Ro 8-9577; (RR,SS)-2-Hydroxy-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine; Tetrabenazine Metabolite; α-Dihydrotetrabenazine; DHTBZ; 1,3,4,6,7,11b-Hexahydro-2-hydroxy-3-(2-methylpropyl)-9,10-dimethoxy-2H-benzo[a]quinolizine
EINECS	Contact for details

Quality Control

Our 9-Desmethyl Tetrabenazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.