Description

Tyrphostin B-46 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for elucidating signal transduction pathways and investigating the role of EGFR in cellular processes such as proliferation and differentiation. It is primarily utilized by researchers and scientists in the fields of oncology, biochemistry, and pharmacology for target validation, high-throughput screening, and mechanistic studies.

Application

• Biochemical Research: A key tool for studying EGFR-mediated signal transduction pathways and cellular signaling cascades.
• Oncology Research: Used in vitro to investigate the role of EGFR in cancer cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Serves as a reference compound and positive control in high-throughput screening assays for identifying novel EGFR inhibitors.
• Pharmacology Studies: Employed to understand the mechanism of action of tyrosine kinase inhibitors and their effects on downstream targets.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology and molecular pharmacology.

Basic Information

Product Name	Tyrphostin B-46
CAS No.	149092-34-2
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 555; Tyrphostin AG 555; RG 50810; 3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile; EGFR Tyrosine Kinase Inhibitor AG 555; 4-Hydroxy-3,5-di-tert-butylbenzylidenemalononitrile; B-46
EINECS	Contact for details

Quality Control

Our Tyrphostin B-46 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation by NMR and mass spectrometry, to ensure high batch-to-batch consistency and reliability for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep under inert atmosphere if handling larger quantities.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.