Description

Piperidine, 2-Fluoro- CAS NO 148991-77-9 is a fluorinated derivative of piperidine, a versatile heterocyclic amine scaffold. This compound is valued for its role as a key building block in medicinal chemistry and advanced material synthesis, where the introduction of fluorine can significantly alter biological activity and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of fluorinated drug candidates, including potential CNS-active compounds, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can enhance metabolic stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands in asymmetric catalysis and organometallic complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and other specialty materials with tailored properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of natural products and biochemical probes for mechanism-of-action studies.
• Custom Synthesis and Contract Manufacturing: A high-purity starting material for custom synthesis projects requiring specific fluorinated piperidine motifs.

Basic Information

Product Name	Piperidine, 2-Fluoro-
CAS No.	148991-77-9
Molecular Formula	C5H10FN
Molecular Weight	103.14 g/mol
Synonyms	2-Fluoropiperidine; 2-Fluoro-piperidine; 2-Fluoropiperidine, 9CI; 2-Fluoro-1-azacyclohexane; 2-Fluoropiperidine hydrochloride (salt form); 2-F-Piperidine; Fluoropiperidine; 2-Fluoropiperidine, AldrichCPR
EINECS	Contact for details

Quality Control

Our Piperidine, 2-Fluoro- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development and commercial needs, from laboratory research to scale-up under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or an opaque secondary container until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.