Description

27-Hydroxy-7-Keto Cholesterol is a significant oxysterol metabolite, playing a crucial role in the study of cholesterol metabolism, oxidative stress, and related signaling pathways. This compound is valued for its high purity and stability, making it an essential reference standard and research reagent in advanced biochemical and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on lipidomics, atherosclerosis research, and the development of biomarkers for metabolic diseases.

Application

• Biochemical Research: Used as a critical reference standard in the study of cholesterol oxidation pathways and oxysterol biology.
• Pharmaceutical R&D: Serves as a key intermediate or analytical standard in drug discovery programs targeting metabolic disorders, such as atherosclerosis and neurodegenerative diseases.
• Diagnostic Development: Employed in the calibration and validation of analytical methods (LC-MS, GC-MS) for quantifying oxysterols in biological samples.
• Lipidomics Studies: An important analyte for mapping lipid metabolic networks and understanding the role of oxidized cholesterol derivatives in cell signaling.
• Academic Research: Utilized in university and institutional labs investigating the link between oxidative stress, inflammation, and chronic disease.
• Quality Control: Acts as a purity standard for ensuring the quality of related biochemical reagents and kits.

Basic Information

Product Name	27-Hydroxy-7-Keto Cholesterol
CAS No.	148988-28-7
Molecular Formula	C27H44O3
Molecular Weight	416.64 g/mol
Synonyms	7-Ketocholesterol-27-ol; 27-Hydroxy-7-oxocholesterol; (25R)-26-Hydroxy-3β-hydroxycholest-5-en-7-one; 7-Oxo-27-hydroxycholesterol; 27-Hydroxycholest-5-en-3β-ol-7-one; Oxysterol 27-H-7-KC; 27-H-7-KC
EINECS	Contact for details

Quality Control

Our 27-Hydroxy-7-Keto Cholesterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. For long-term storage, consider keeping the product under an inert atmosphere at -20°C or below to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.