Description

Tyrphostin Ag 879 CAS NO 148741-30-4 is a potent and selective inhibitor of the platelet-derived growth factor receptor (PDGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and angiogenesis. It is primarily utilized by researchers and scientists in the fields of oncology, pharmacology, and biochemistry for in vitro and in vivo studies.

Application

• Biochemical Research: A key reagent for investigating PDGFR-mediated signaling cascades and their role in cell growth and differentiation.
• Oncology Studies: Used to explore the therapeutic potential of PDGFR inhibition in various cancer models, including gliomas and sarcomas.
• Pharmacological Screening: Serves as a reference standard and active compound in high-throughput screening assays for novel kinase inhibitors.
• Angiogenesis Research: Applied in studies targeting tumor vasculature development, as PDGFR signaling is involved in pericyte recruitment.
• Academic & Industrial R&D: Essential for basic science discovery and preclinical drug development programs in pharmaceutical and biotech companies.

Basic Information

Product Name	Tyrphostin Ag 879
CAS No.	148741-30-4
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 879; Tyrphostin AG 879; 3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile; PDGFR Tyrosine Kinase Inhibitor AG879; NSC 364372; 2-[(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene]propanedinitrile; 4-Hydroxy-3,5-di-tert-butylbenzylidenemalononitrile
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 879 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.