Description

Squalamine CAS NO 148717-90-2 is a naturally occurring, water-steroidal polyamine compound originally isolated from the dogfish shark. This compound is of significant commercial and research interest due to its broad-spectrum antimicrobial and anti-angiogenic properties. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents targeting cancer, infectious diseases, and ophthalmic conditions.

Application

• Oncology Research & Drug Development: Investigation as a potential anti-cancer agent due to its ability to inhibit tumor angiogenesis and induce apoptosis in certain cancer cell lines.
• Antimicrobial Agent Development: Research into its potent bactericidal and fungicidal activity for creating new classes of antibiotics, particularly against drug-resistant strains.
• Ophthalmic Pharmaceuticals: Exploration in treatments for age-related macular degeneration (AMD) and other retinal diseases linked to abnormal blood vessel growth.
• Virology Studies: Evaluation of its antiviral properties against a range of enveloped viruses, including some influenza strains and herpesviruses.
• Biochemical Research: Used as a reference standard and active pharmaceutical ingredient (API) in pharmacokinetic, pharmacodynamic, and mechanism-of-action studies.
• Cosmeceutical R&D: Investigation for potential applications in advanced skincare formulations targeting inflammation and microbial balance.

Basic Information

Product Name	Squalamine
CAS No.	148717-90-2
Molecular Formula	C34H65N3O5S
Molecular Weight	627.96 g/mol
Synonyms	MSI-1256F; Squalamine Lactate; 3β-N-1-{N-[3-(4-Aminobutyl)]-1,3-diaminopropane}-7α,24ζ-dihydroxy-5α-cholestane 24-sulfate; Aminosterol 1436; SQ-28,603; NSC-725782; Shark Liver Aminosterol
EINECS	Contact for details

Quality Control

Our Squalamine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (NMR, MS), and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.