Description

8-(3-Chlorostyryl)Caffeine is a synthetic xanthine derivative and a potent adenosine receptor antagonist. This compound is of significant interest in biochemical and pharmacological research due to its modified structure, which enhances its receptor binding affinity and selectivity compared to caffeine. It is primarily utilized by research institutions and pharmaceutical development companies investigating neurological pathways, cardiovascular function, and as a key intermediate in the synthesis of more complex therapeutic agents.

Application

• Pharmacological Research: Used as a reference standard and active compound in studies targeting adenosine A1 and A2A receptors.
• Neurological Studies: Investigated for its effects on neuroprotection, sleep-wake cycles, and locomotor activity in preclinical models.
• Chemical Intermediate: Serves as a crucial building block for the synthesis of novel xanthine-based drug candidates and diagnostic tools.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to discover new receptor modulators.
• Academic Research: Utilized in university and institutional labs for fundamental studies on purinergic signaling.

Basic Information

Product Name	8-(3-Chlorostyryl)Caffeine
CAS No.	148589-13-3
Molecular Formula	C18H17ClN4O2
Molecular Weight	356.81 g/mol
Synonyms	8-[(E)-2-(3-Chlorophenyl)ethenyl]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione; 8-(3-Chlorostyryl)-1,3,7-trimethylxanthine; 8-(3-Chlorostyryl)theophylline; 3,7-Dihydro-1,3,7-trimethyl-8-[(E)-2-(3-chlorophenyl)ethenyl]-1H-purine-2,6-dione; 8-Styrylcaffeine derivative; A2A Adenosine Receptor Antagonist; CSC analog
EINECS	Contact for details

Quality Control

Our 8-(3-Chlorostyryl)Caffeine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider sealing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.