Description

3-Bromomethylbenzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a sulfonyl chloride and a benzylic bromide group, makes it an indispensable reagent for introducing the sulfonyl moiety and for further functionalization via nucleophilic substitution. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), intermediates, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, including protease inhibitors, kinase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that incorporate sulfonylurea or sulfonamide functional groups.
• Peptide Chemistry: Acts as a sulfonylation reagent for amino group protection (e.g., creating Bsmoc-type protecting groups) in solid-phase peptide synthesis (SPPS).
• Material Science: Intermediate in the synthesis of specialty polymers, dyes, and photoinitiators where sulfone linkages are required.
• Chemical Biology & Proteomics: Useful for designing activity-based probes (ABPs) or affinity labels to study enzyme function and protein interactions.
• Cross-Coupling Reactions: The benzylic bromide moiety can participate in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.

Basic Information

Product Name	3-Bromomethylbenzenesulfonyl Chloride
CAS No.	148583-69-1
Molecular Formula	C7H6BrClO2S
Molecular Weight	269.54 g/mol
Synonyms	α-Bromo-m-toluenesulfonyl Chloride; 3-(Bromomethyl)benzenesulfonyl Chloride; m-(Bromomethyl)benzenesulfonyl Chloride; 1-(Bromomethyl)-3-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 3-(bromomethyl)-; m-Bromomethylphenylsulfonyl Chloride; 3-Bromobenzylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Bromomethylbenzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC/NMR), identity (by FT-IR), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.