Description

Grk2I CAS NO 148505-03-7 is a high-purity, specialized chemical compound used as a potent and selective inhibitor of G protein-coupled receptor kinase 2 (GRK2). This compound matters for researchers and developers in the life sciences sector as it is a critical tool for modulating intracellular signaling pathways, enabling the study of cardiac function, inflammation, and various GPCR-related diseases. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on drug discovery and molecular biology.

Application

• Biochemical Research: A key reagent for studying GRK2-mediated signaling cascades and receptor desensitization in vitro.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery of novel therapeutics targeting heart failure and hypertension.
• Cell Biology Studies: Used to investigate the role of GRK2 in cell migration, proliferation, and immune cell function.
• Enzyme Inhibition Assays: Acts as a selective inhibitor in high-throughput screening (HTS) platforms to identify new drug candidates.
• Academic Research: Essential for fundamental research into G protein-coupled receptor (GPCR) biology and related pathological mechanisms.

Basic Information

Product Name	Grk2I
CAS No.	148505-03-7
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	GRK2 Inhibitor; 3-[(4-Methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine; (3-(4-Methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine); G-Protein-Coupled Receptor Kinase 2 Inhibitor; GRK2I Compound; CAS 148505-03-7; 1H-Pyrrolo[2,3-b]pyridine, 3-[(4-methylphenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our Grk2I is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.