Description

Sarakalim is a potassium channel opener belonging to the benzopyran chemical class, identified by CAS No. 148430-28-8. This compound is of significant interest in pharmacological research for its role in modulating vascular smooth muscle tone and cellular electrophysiology. It is primarily utilized by researchers and developers in the pharmaceutical and life sciences sectors for cardiovascular research, drug discovery, and as a reference standard.

Application

• Pharmacological Research: Used as a potent and selective ATP-sensitive potassium (KATP) channel opener to study vasodilation, cardioprotection, and smooth muscle relaxation mechanisms.
• Cardiovascular Drug Discovery: Serves as a key reference compound and intermediate in the development of novel therapeutic agents targeting hypertension, angina, and ischemic heart disease.
• Biochemical Assays: Employed as a standard in in vitro and in vivo assays to investigate ion channel function and cellular signaling pathways.
• Academic & Institutional Research: A critical tool for universities and research institutes conducting fundamental studies on potassium channel physiology and pharmacology.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical analysis.

Basic Information

Product Name	Sarakalim
CAS No.	148430-28-8
Molecular Formula	C17H20N2O3S
Molecular Weight	332.42 g/mol
Synonyms	SR 44866; (±)-Sarakalim; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-3-ol; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-chromen-3-ol; Potassium channel opener SR 44866; Benzopyran potassium channel activator
EINECS	Contact for details

Quality Control

Our Sarakalim is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.