Description

(+)-(1R,2R)-o-Desmethyl Tramadol Hcl is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for analytical research, method development, and the synthesis of specialized pharmaceutical agents. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical development companies engaged in neuropharmacology and pain management research.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, GC-MS) of related compounds in research and quality control laboratories.
• Metabolite Studies: Serves as a key analytical standard for the identification and quantification of tramadol metabolites in pharmacokinetic and bioequivalence studies.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the research-scale synthesis of novel analgesic compounds and for structure-activity relationship (SAR) studies.
• Forensic and Clinical Toxicology: Acts as a certified reference material (CRM) for the accurate detection and confirmation of substances in forensic analysis and clinical toxicology reports.
• Biochemical Research: Utilized in vitro studies to investigate opioid receptor interactions and the pharmacological profiles of enantiomerically pure substances.

Basic Information

Product Name	(+)-(1R,2R)-o-Desmethyl Tramadol Hydrochloride
CAS No.	148262-77-5
Molecular Formula	C15H23NO2 • HCl
Molecular Weight	285.81 g/mol (as hydrochloride salt)
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; O-Desmethyltramadol (M1 Metabolite) Hydrochloride; (+)-O-Desmethyltramadol HCl; (1R,2R)-Tramadol Metabolite M1 HCl; (1R,2R)-M1 Tramadol HCl; DSM1
EINECS	Contact for details

Quality Control

Our (+)-(1R,2R)-o-Desmethyl Tramadol Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including chiral purity verification, assay, and identification by spectroscopic methods (IR, NMR) to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (1R,2R enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.