Description

1-Chloro-2-Ethynyl-4-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block characterized by its unique combination of a reactive ethynyl group and a stable trifluoromethyl substituent. This compound is essential for advanced organic synthesis, enabling the construction of complex molecular architectures with tailored electronic and steric properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Click Chemistry: The terminal alkyne moiety makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Ligand and Catalyst Development: Employed in the design of novel organometallic complexes and catalytic systems.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships (SAR) influenced by fluorine substitution.

Basic Information

Product Name	1-Chloro-2-Ethynyl-4-(Trifluoromethyl)Benzene
CAS No.	148258-94-0
Molecular Formula	C9H4ClF3
Molecular Weight	204.58 g/mol
Synonyms	2-Chloro-1-ethynyl-4-(trifluoromethyl)benzene; 1-Chloro-2-ethynyl-α,α,α-trifluoro-p-xylene; 4-Chloro-3-(trifluoromethyl)phenylacetylene; 2-Ethynyl-1-chloro-4-(trifluoromethyl)benzene; 3-Chloro-4-ethynylbenzotrifluoride; (2-Chloro-4-(trifluoromethyl)phenyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Ethynyl-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.