Description

Spongistatin 1 is a complex macrocyclic lactone polyether, a potent marine-derived secondary metabolite with significant biological activity. This compound is highly valued in advanced biochemical and pharmacological research due to its unique mechanism of action as a non-competitive inhibitor of tubulin polymerization. It is primarily sought after by research institutions and pharmaceutical development laboratories focused on oncology, cell biology, and the discovery of novel therapeutic agents targeting microtubule dynamics.

Application

• Biochemical Research: Used as a highly specific and potent tool compound to study microtubule assembly and dynamics in cell biology.
• Anticancer Agent Discovery: Serves as a reference standard and lead compound in the screening and development of novel chemotherapeutic agents.
• Mechanism of Action Studies: Employed to investigate cell cycle arrest, apoptosis, and other cellular processes affected by microtubule disruption.
• Pharmaceutical Reference Standard: Utilized for analytical method development, validation, and quality control in drug discovery pipelines.
• Marine Natural Product Research: Acts as a key compound for studying structure-activity relationships (SAR) within the spongistatin class of molecules.

Basic Information

Product Name	Spongistatin 1
CAS No.	148179-94-6
Molecular Formula	C₄₈H₇₀O₁₇
Molecular Weight	943.1 g/mol
Synonyms	Spongistatin 1; Spongistatin I; (1R,2R,4S,5R,6R,8R,10S,11S,12S,13R,15S,17R,19S,20R,21S,23R,24S,25S,27R,28S,29R,30S,32R,33S,34R,35S,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S,50R,51S,52R,53S,54R,55S,56R,57S,58R,59S,60R,61S,62R,63S,64R,65S,66R,67S,68R,69S,70R)-70-[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-methyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,4,5,6,8,10,11,12,13,15,17,19,20,21,23,24,25,27,28,29,30,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69-heptacontahydroxyheptacontyl 3,4,5-trihydroxy-6-methyloxane-2-carboxylate
EINECS	Contact for details

Quality Control

Our Spongistatin 1 is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided, ensuring traceability and compliance with the specifications required for high-end biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.