Description

Ca-074 Me is a potent and cell-permeable inhibitor of the cysteine protease cathepsin B. This compound is a critical research tool for studying protease function in various biological pathways, offering high selectivity and efficacy. It is primarily utilized by researchers and scientists in the fields of biochemistry, cell biology, and pharmaceutical development for investigating disease mechanisms related to cancer, inflammation, and neurodegeneration.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles of cathepsin B in enzymatic assays and in vitro systems.
• Cell Biology Studies: Employed to probe cathepsin B activity in cellular processes, including apoptosis, protein degradation, and tumor invasion.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for validating targets and screening new therapeutic agents in oncology and inflammatory diseases.
• Neuroscience Research: Applied in models to understand the involvement of cathepsin B in neuroinflammatory conditions and neurodegenerative disorders.
• Academic & Institutional Laboratories: A standard reagent for graduate and post-doctoral research projects focused on protease biology.

Basic Information

Product Name	Ca-074 Me
CAS No.	147859-80-1
Molecular Formula	C₂₀H₃₄N₄O₇S
Molecular Weight	474.57 g/mol
Synonyms	(L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester; CA-074 Methyl Ester; Cathepsin B Inhibitor II; Z-FA-FMK (related analog); N-[(L-3-trans-Carboxyoxiran-2-carbonyl)-L-leucyl]agmatine Methyl Ester; Epoxysuccinyl Derivative; E-64d analog; Protease Inhibitor Ca-074 Me
EINECS	Contact for details

Quality Control

Our Ca-074 Me is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.